Description
Product Characteristics:
Involved in the targeting and/or fusion of transport vesicles to their target membrane during transport of proteins from the early endosome to the lysosome. Required for heterotypic fusion of late endosomes with lysosomes and homotypic lysosomal fusion. Required for calcium regulated lysosomal exocytosis. Involved in the export of chylomicrons from the endoplasmic reticulum to the cis Golgi. Required for exocytosis of mediators during eosinophil and neutrophil degranulation, and target cell killing by natural killer cells. Required for focal exocytosis of late endocytic vesicles during phagosome formation.
Subcellular location: Cytoplasm
Synonyms: FLJ53045, FLJ53762, FLJ54296, HGNC:11486, OTTHUMP00000024258, OTTHUMP00000024259, OTTHUMP00000225953, SYBL 1, SYBL1, Synaptobrevin like 1, Synaptobrevin-like protein 1, Tetanus insensitive VAMP, Tetanus neurotoxin insensitive VAMP, Tetanus-insensitive VAMP, TI VAMP, Ti-VAMP, TIVAMP, VAMP-7, VAMP7, VAMP7_HUMAN, Vesicle-associated membrane protein 7.
Target Information: This gene encodes a transmembrane protein that is a member of the soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) family. The encoded protein localizes to late endosomes and lysosomes and is involved in the fusion of transport vesicles to their target membranes. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Jun 2010]